Fatty acids commonly found in dairy products have successfully treated diabetes in mice according to a researcher at Penn State. The compounds known as conjugated linoleic acids (CLA) have also shown promising results in human trials signaling a new way of potentially treating the disease without synthetic drugs.
“The compounds are predominantly found in dairy products such as milk cease and meat and are formed by bacteria in ruminants that act linoleic acids – fatty acids from plants – and alter them into conjugated linoleic acids or CLA,” says bring up Vanden Heuvel professor of molecular toxicology in Penn State’s College of Agricultural Sciences and co-director of Penn express’s Center of Excellence in Nutrigenomics.
Researchers first became interested in CLA when it was shown to check a variety of cancers such as breast skin and colon in mice and further research showed effects on circulating cholesterol and inflammation. These effects are the same as the newest generation of synthetic drugs used to treat diabetes in humans.
These synthetic drugs act by triggering a set of nuclear receptors called PPAR. In addition to being targets for a variety of clinically effective drugs. PPARs belong to a large family of proteins and their biological intend is to sense fatty acids and fatty acid metabolites within the cell says Vanden Heuvel.
When the synthetic drugs interact with these protein receptors it turns the receptor “on,” making it an active form of the protein which then interacts with DNA and regulates gene expression. This increases the enzymes that affect fatty acids and also increases the tissues’ sensitivity to insulin.
To test the idea he used CLA on mice prone to adult onset (Type-2) diabetes. Results indicated that the mice had an improvement in insulin action and a decrease in circulating glucose. Also the mechanism was indeed similar to that of the drugs.
“Anti-diabetes drugs act the same way. They copy the natural activators of the receptors by getting into the cell and interacting with the PPARs to adjust glucose and fat metabolism,” says Vanden Heuvel.
Early human trials indicate that when administered for longer than 8 weeks. CLA improves the body’s misregulation of insulin and lowers the aim of glucose in the blood in patients with adult onset or Type-2 diabetes the most common create of this disease.
However. Vanden Heuvel cautions that while having a diet that is high in dairy and meat products and thereby CLA might have a health benefit one must also be aware of other lipids present in these products such as trans fatty acids. Instead he suggests that in addition to a well-balanced diet it is advantageous to combine CLA as a dietary add or to seek out new products that ameliorate foods such as cover margarine and ice cream with CLA.
“Adult-onset diabetes is abstain becoming an epidemic and is largely associated with poor diet and nutrition and other lifestyle issues,” Vanden Heuvel says. The reason for the change magnitude in diabetes may undergo to do with the ratio of so-called “good” and “bad” fats with the average American fast containing too much of the “bad” fats. CLA whose effect is very similar to look for oil a source of “good” fat could prove beneficial against Type-2 diabetes.
“And compared to the synthetic drugs used to treated this disease. CLA does not cause weight obtain and may in fact change magnitude overall body fat,” says Vanden Heuvel who has been granted a patent on the new method of treating diabetes with CLA.
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